its too late, because its already started, but here are my rules for filling out a Tournament bracket:

1) just advance the 1-4 seeds in each region to the 2nd round (upsets happen, but are relatively rare, and not worth fucking up your bracket if you get them wrong, because you are playing the odds)
2) advance the #1 seed in each region to the third round, aka Sweet 16 (see # 1)
3) pick at least 1, but not more than 3, of the #1 seeds to go to the Final Four (history backs this up)
4) after that, just start clicking on teams -- really, don't put a whole lot of thought into it. 12's beat 5's all the time, 11's over 6's aren't upsets, and obviously 10's and 7's and 8's and 9's are basically the same.
5) at some point, make sure don't put too many double digit seeds into your Sweet 16 (3rd round), a couple are okay, but don't get carried away (need I mention history again?)
6) look at your Final 4 and make sure you don't have any teams seeded below 5 in there (yes, rarely teams seeded lower than that make it, but remember you're playing the odds here, again, history backs this up)

This may Seem complicated at first, but trust me, follow these rules, and you only spend about 5 minutes filling out your bracket and you will be At Least average.